avitriptan [Ligand Id: 10446] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2110755 (Avitriptan)
  • 5-HT1A receptor in Rat [GtoPdb: 1] [UniProtKB: P19327]
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  • 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
  • 5-HT1B receptor in Rat [GtoPdb: 2] [UniProtKB: P28564]
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  • 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1A receptor in Rat [GtoPdb: 1] [UniProtKB: P19327]
GtoPdb - - 7.15 pKi 70.8 nM Ki Naunyn Schmiedebergs Arch Pharmacol (1997) 355: 295-302 [PMID:9050026]
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 7.68 pKi 20.9 nM Ki Naunyn Schmiedebergs Arch Pharmacol (1997) 355: 295-302 [PMID:9050026]
5-HT1B receptor in Rat [GtoPdb: 2] [UniProtKB: P28564]
GtoPdb - - 7.44 pKi 36.3 nM Ki Naunyn Schmiedebergs Arch Pharmacol (1997) 355: 295-302 [PMID:9050026]
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 8.36 pKi 4.37 nM Ki Naunyn Schmiedebergs Arch Pharmacol (1997) 355: 295-302 [PMID:9050026]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]