FK-881 [Ligand Id: 10241] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL3427203
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of COX1 (unknown origin) B 8.3 pIC50 5 nM IC50 ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228]
ChEMBL Inhibition of LPS-induced COX1 in human whole blood assessed as reduction in TXB2 levels by radioimmunoassay B 8.31 pIC50 4.9 nM IC50 Eur J Med Chem (2015) 94: 252-264 [PMID:25768707]
GtoPdb - - 8.31 pIC50 4.9 nM IC50 Biochem Pharmacol (2011) 82: 746-54 [PMID:21745460]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
GtoPdb - - 5.49 pIC50 3200 nM IC50 Biochem Pharmacol (2011) 82: 746-54 [PMID:21745460]
ChEMBL Inhibition of LPS-induced COX2 in human whole blood assessed as reduction in PGH2 levels by radioimmunoassay B 5.49 pIC50 3200 nM IC50 Eur J Med Chem (2015) 94: 252-264 [PMID:25768707]
ChEMBL Inhibition of COX2 (unknown origin) B 5.49 pIC50 3200 nM IC50 ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]