G Protein-Coupled Receptor List | IUPHAR/BPS Guide to PHARMACOLOGY

G protein-coupled receptors

Download the list of all GPCR targets in CSV format

Calcium-sensing receptor
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
Calcium-sensing receptor	Ca²⁺ L-tryptophan Mg²⁺ spermine	CaS receptor	CASR	Casr	Casr
Class C Orphans
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
Class C Orphans		GPR156	GPR156	Gpr156	Gpr156
Class C Orphans		GPR158	GPR158	Gpr158	Gpr158	aka KIAA1136
Class C Orphans		GPR179	GPR179	Gpr179	Gpr179
Class C Orphans		GPRC5A	GPRC5A	Gprc5a	Gprc5a
Class C Orphans		GPRC5B	GPRC5B	Gprc5b	Gprc5b
Class C Orphans		GPRC5C	GPRC5C	Gprc5c	Gprc5c
Class C Orphans		GPRC5D	GPRC5D	Gprc5d	Gprc5d
Class C Orphans	glycine L-alanine L-arginine L-citrulline L-glutamine L-lysine L-ornithine L-serine	GPRC6 receptor	GPRC6A	Gprc6a	Gprc6a
GABA_B receptors
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
GABA_B receptors	GABA	GABA_B receptor				Functional GABA receptors contain both GABA_B1 and GABA_B2 subunits
GABA_B receptors	GABA	GABA_B1	GABBR1	Gabbr1	Gabbr1
GABA_B receptors		GABA_B2	GABBR2	Gabbr2	Gabbr2
Metabotropic glutamate receptors
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
Metabotropic glutamate receptors	L-glutamic acid	mGlu₁ receptor	GRM1	Grm1	Grm1	Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors	L-glutamic acid	mGlu₂ receptor	GRM2	Grm2	Grm2	Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors	L-glutamic acid NAAG	mGlu₃ receptor	GRM3	Grm3	Grm3	Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors	L-glutamic acid L-serine-O-phosphate	mGlu₄ receptor	GRM4	Grm4	Grm4	Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors	L-glutamic acid	mGlu₅ receptor	GRM5	Grm5	Grm5	Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors	L-glutamic acid L-serine-O-phosphate	mGlu₆ receptor	GRM6	Grm6	Grm6	Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors	L-glutamic acid L-serine-O-phosphate	mGlu₇ receptor	GRM7	Grm7	Grm7	Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors	L-glutamic acid L-serine-O-phosphate	mGlu₈ receptor	GRM8	Grm8	Grm8	Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Taste 1 receptors
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
Taste 1 receptors		TAS1R1	TAS1R1	Tas1r1	Tas1r1
Taste 1 receptors		TAS1R2	TAS1R2		Tas1r2
Taste 1 receptors		TAS1R3	TAS1R3	Tas1r3	Tas1r3