Nerve growth factor IB-like receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [2]) have yet to be officially paired with an endogenous ligand.

* Key recommended reading is highlighted with an asterisk

* Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V. (2006) International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev, 58 (4): 798-836. [PMID:17132856]

* Germain P, Staels B, Dacquet C, Spedding M, Laudet V. (2006) Overview of nomenclature of nuclear receptors. Pharmacol Rev, 58 (4): 685-704. [PMID:17132848]

Huang P, Chandra V, Rastinejad F. (2010) Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics. Annu Rev Physiol, 72: 247-72. [PMID:20148675]

McMorrow JP, Murphy EP. (2011) Inflammation: a role for NR4A orphan nuclear receptors?. Biochem Soc Trans, 39 (2): 688-93. [PMID:21428963]

Mohan HM, Aherne CM, Rogers AC, Baird AW, Winter DC, Murphy EP. (2012) Molecular pathways: the role of NR4A orphan nuclear receptors in cancer. Clin Cancer Res, 18 (12): 3223-8. [PMID:22566377]

Pearen MA, Muscat GE. (2010) Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease. Mol Endocrinol, 24 (10): 1891-903. [PMID:20392876]

* Ranhotra HS. (2015) The NR4A orphan nuclear receptors: mediators in metabolism and diseases. J Recept Signal Transduct Res, 35 (2): 184-8. [PMID:25089663]

* Rodríguez-Calvo R, Tajes M, Vázquez-Carrera M. (2017) The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases. Expert Opin Ther Targets, 21 (3): 291-304. [PMID:28055275]

* Safe S, Jin UH, Morpurgo B, Abudayyeh A, Singh M, Tjalkens RB. (2016) Nuclear receptor 4A (NR4A) family - orphans no more. J Steroid Biochem Mol Biol, 157: 48-60. [PMID:25917081]

Sladek FM. (2011) What are nuclear receptor ligands?. Mol Cell Endocrinol, 334 (1-2): 3-13. [PMID:20615454]

van Tiel CM, de Vries CJ. (2012) NR4All in the vessel wall. J Steroid Biochem Mol Biol, 130 (3-5): 186-93. [PMID:21277978]

Zhao Y, Bruemmer D. (2010) NR4A orphan nuclear receptors: transcriptional regulators of gene expression in metabolism and vascular biology. Arterioscler Thromb Vasc Biol, 30 (8): 1535-41. [PMID:20631354]

1. Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ. (2003) The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell, 113 (6): 731-42. [PMID:12809604]

2. Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V. (2006) International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev, 58 (4): 798-836. [PMID:17132856]

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5. Zhan Y, Du X, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC et al.. (2008) Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat Chem Biol, 4 (9): 548-56. [PMID:18690216]