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Overview
Aminoacyltransferases are ezymes that catalyse the transfer of an aminoacyl group from donor to acceptor, forming an ester or amide bond. There are 23 sub-families of aminoacyltransferase enzymes including peptidyl transferases, leucyltransferases, transglutaminases, and several families of ubiquitin-conjugating and transferases.
How to cite this family page
Database page citation:
2.3.2.- Aminoacyltransferases. Accessed on 04/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=978.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.
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Human RING-type E3 ubiquitin transferases (also known as ubiquitin ligases) include several groupings based on structure and function, of which 70 are tripartite motif (TRIM)-containing proteins. Whilst these 70 share conserved structural domains, they mediate diverse cellular functions.