GRK4 subfamily | Enzymes | IUPHAR/BPS Guide to MALARIA PHARMACOLOGY

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Kinases (EC 2.7.x.x)
AGC: Containing PKA, PKG, PKC families
G protein-coupled receptor kinases (GRKs)
GRK4 subfamily

GRK4 subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

GRK4 (G protein-coupled receptor kinase 4) Show summary »« Hide summary More detailed page go icon to follow link

GRK5 (G protein-coupled receptor kinase 5) Show summary »« Hide summary More detailed page go icon to follow link

GRK6 (G protein-coupled receptor kinase 6) Show summary »« Hide summary More detailed page go icon to follow link

References

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1. Cho SY, Lee BH, Jung H, Yun CS, Ha JD, Kim HR, Chae CH, Lee JH, Seo HW, Oh KS. (2013) Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors. Bioorg Med Chem Lett, 23 (24): 6711-6. [PMID:24210504]

2. Pronin AN, Benovic JL. (1997) Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C. J Biol Chem, 272 (6): 3806-12. [PMID:9013639]

3. Sallese M, Mariggiò S, Collodel G, Moretti E, Piomboni P, Baccetti B, De Blasi A. (1997) G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells. J Biol Chem, 272 (15): 10188-95. [PMID:9092566]

How to cite this family page

Database page citation:

GRK4 subfamily. Accessed on 25/04/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=937.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.