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Kelch-like proteins
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
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More detailed introduction 
Keap1 is involved in the Keap1-Nrf2-ARE signaling pathway that is essential for protecting cells from oxidative stress. Nrf2 = nuclear factor erythroid 2-related factor 2; ARE = antioxidant response elements.
Targets
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kelch like ECH-associated protein 1
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How to cite this family page
Database page citation:
Kelch-like proteins. Accessed on 23/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=876.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Cidlowski JA, Davenport AP, Fabbro D, Spedding M, Striessnig J, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets. Br J Pharmacol. 182: S1-S23.
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