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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
aldehyde dehydrogenase 2 family member Show summary »« Hide summary More detailed page
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aldo-keto reductase family 1 member B Show summary »« Hide summary More detailed page
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VAP-1 (amine oxidase copper containing 3) Show summary »« Hide summary More detailed page
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catalase C Show summary »« Hide summary More detailed page
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DHFR (dihydrofolate reductase) C Show summary »« Hide summary More detailed page
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DHODH (dihydroorotate dehydrogenase (quinone)) C Show summary »« Hide summary More detailed page
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glutathione-disulfide reductase Show summary »« Hide summary More detailed page
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hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Show summary »« Hide summary More detailed page
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4-hydroxyphenylpyruvate dioxygenase Show summary »« Hide summary More detailed page
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11-βHSD1 (hydroxysteroid 11-beta dehydrogenase 1) Show summary »« Hide summary More detailed page
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11-βHSD2 (hydroxysteroid 11-beta dehydrogenase 2) Show summary »« Hide summary More detailed page
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hydroxysteroid 17-beta dehydrogenase 2 Show summary »« Hide summary More detailed page
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hydroxysteroid 17-beta dehydrogenase 13 Show summary »« Hide summary
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IMPDH1 (inosine monophosphate dehydrogenase 1) C Show summary »« Hide summary More detailed page
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IMPDH2 (inosine monophosphate dehydrogenase 2) C Show summary »« Hide summary More detailed page
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myeloperoxidase Show summary »« Hide summary More detailed page
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sepiapterin reductase Show summary »« Hide summary More detailed page
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steroid 5 alpha-reductase 2 Show summary »« Hide summary More detailed page
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tyrosinase Show summary »« Hide summary More detailed page
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vitamin K epoxide reductase complex subunit 1 Show summary »« Hide summary More detailed page
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XDH (xanthine dehydrogenase) C Show summary »« Hide summary More detailed page
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* Key recommended reading is highlighted with an asterisk
* Baber MA, Crist CM, Devolve NL, Patrone JD. (2023) Tyrosinase Inhibitors: A Perspective. Molecules, 28 (15). [PMID:37570734]
* Feng D, Fang Z, Zhang P. (2022) The melanin inhibitory effect of plants and phytochemicals: A systematic review. Phytomedicine, 107: 154449. [PMID:36126406]
* Ullah S, Son S, Yun HY, Kim DH, Chun P, Moon HR. (2016) Tyrosinase inhibitors: a patent review (2011-2015). Expert Opin Ther Pat, 26 (3): 347-62. [PMID:26815044]
1. Asanuma M, Miyazaki I, Ogawa N. (2003) Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease. Neurotox Res, 5 (3): 165-76. [PMID:12835121]
2. Bevans CG, Krettler C, Reinhart C, Tran H, Koßmann K, Watzka M, Oldenburg J. (2013) Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay. Biochim Biophys Acta, 1830 (8): 4202-10. [PMID:23618698]
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12. Rabe T, Kiesel L, Kellermann J, Weidenhammer K, Runnebaum B, Potts GO. (1983) Inhibition of human placental progesterone synthesis and aromatase activity by synthetic steroidogenic inhibitors in vitro. Fertil Steril, 39 (6): 829-35. [PMID:6574022]
13. Rosowsky A, Mota CE, Queener SF, Waltham M, Ercikan-Abali E, Bertino JR. (1995) 2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii. J Med Chem, 38 (5): 745-52. [PMID:7877140]
14. Schilter HC, Collison A, Russo RC, Foot JS, Yow TT, Vieira AT, Tavares LD, Mattes J, Teixeira MM, Jarolimek W. (2015) Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration. Respir Res, 16: 42. [PMID:25889951]
15. Singh SB, Malamas MS, Hohman TC, Nilakantan R, Carper DA, Kitchen D. (2000) Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants. J Med Chem, 43 (6): 1062-70. [PMID:10737739]
16. Smith DJ, Vainio P, Mikkola J, Vuorio P, Vainio J. (2011) Fully human anti-VAP-1 monoclonal antibodies. Patent number: US7897149 B2. Assignee: Biotie Therapies Corp.. Priority date: 20/04/2007. Publication date: 01/03/2011.
17. Tajima R, Oozeki H, Muraoka S, Tanaka S, Motegi Y, Nihei H, Yamada Y, Masuoka N, Nihei K. (2011) Synthesis and evaluation of bibenzyl glycosides as potent tyrosinase inhibitors. Eur J Med Chem, 46 (4): 1374-81. [PMID:21334791]
18. Thamm S, Willwacher MK, Aspnes GE, Bretschneider T, Brown NF, Buschbom-Helmke S, Fox T, Gargano EM, Grabowski D, Hoenke C et al.. (2023) Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science. J Med Chem, 66 (4): 2832-2850. [PMID:36727857]
19. TOOHEY M. (1952) Antagonism of anticoagulants dicoumarol, tromexan, and phenylindandione by vitamin K. Br Med J, 2 (4786): 687-90. [PMID:12978288]
20. Wallin R, Wajih N, Hutson SM. (2008) VKORC1: a warfarin-sensitive enzyme in vitamin K metabolism and biosynthesis of vitamin K-dependent blood coagulation factors. Vitam Horm, 78: 227-46. [PMID:18374197]
21. Zhang R, Piao MJ, Oh MC, Park JE, Shilnikova K, Moon YJ, Kim DH, Jung U, Kim IG, Hyun JW. (2016) Protective Effect of an Isoflavone, Tectorigenin, Against Oxidative Stress-induced Cell Death via Catalase Activation. J Cancer Prev, 21 (4): 257-263. [PMID:28053960]
Database page citation:
1.-.-.- Oxidoreductases. Accessed on 03/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=840.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.
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