Type IX RTKs: MuSK | Catalytic receptors | IUPHAR/BPS Guide to MALARIA PHARMACOLOGY

Type IX RTKs: MuSK C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The muscle-specific kinase MuSK is associated with the formation and organisation of the neuromuscular junction from the skeletal muscle side. Agrin (AGRN, O00468) forms a complex with low-density lipoprotein receptor-related protein 4 (LRP4, O75096) to activate MuSK [1].

Receptors

MuSK (muscle associated receptor tyrosine kinase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1847

Nomenclature

muscle associated receptor tyrosine kinase

Common abbreviation

MuSK

Previous and unofficial names

muscle specific kinase (neural fold/somite kinase 1) | muscle-specific tyrosine protein kinase receptor | Nsk1 | MDK4 | Nsk2 | Nsk3 | muscle, skeletal, receptor tyrosine kinase | muscle

Genes

MUSK (Hs), Musk (Mm), Musk (Rn)

Ensembl ID

ENSG00000030304 (Hs), ENSMUSG00000057280 (Mm), ENSRNOG00000033567 (Rn)

UniProtKB AC

O15146 (Hs), Q61006 (Mm), Q62838 (Rn)

EC number

2.7.10.1

Comment

MuSK associates with the neural agrin (AGRN; O00468)-bound low-density lipoprotein receptor-related protein 4 (LRP4). MuSK-mediated phosphorylation of downstream targets is involved in stabilising neuromuscular function.

Comments

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References

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How to cite this family page

Database page citation:

Type IX RTKs: MuSK. Accessed on 25/04/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=793.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.