Sphingolipid Δ<sup>4</sup>-desaturase | Enzymes | IUPHAR/BPS Guide to MALARIA PHARMACOLOGY

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Sphingolipid Δ⁴-desaturase

Sphingolipid Δ⁴-desaturase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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DEGS1 and DEGS2 are 4TM proteins.

Enzymes

delta 4-desaturase, sphingolipid 1 C Show summary »« Hide summary

Target Id

2484

Nomenclature

delta 4-desaturase, sphingolipid 1

Previous and unofficial names

Genes

DEGS1 (Hs), Degs1 (Mm), Degs1 (Rn)

Ensembl ID

ENSG00000143753 (Hs), ENSMUSG00000038633 (Mm), ENSRNOG00000003223 (Rn)

UniProtKB AC

O15121 (Hs), O09005 (Mm), Q5XIF5 (Rn)

EC number

1.14.-.-

Cofactors

NAD

Inhibitors

SKI II pK_i 6.5 [3]

RBM2-1B pIC₅₀ 4.7 [2]

Comment

Myristoylation of DEGS1 enhances its activity and targets it to the mitochondria [1].

delta 4-desaturase, sphingolipid 2 C Show summary »« Hide summary

Target Id

2485

Nomenclature

delta 4-desaturase, sphingolipid 2

Previous and unofficial names

DES2 | FADS8 | degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase | delta(4)-desaturase, sphingolipid 2 | delta(4)-desaturase

Genes

DEGS2 (Hs), Degs2 (Mm), Degs2 (Rn)

Ensembl ID

ENSG00000168350 (Hs), ENSMUSG00000021263 (Mm), ENSRNOG00000011716 (Rn)

UniProtKB AC

Q6QHC5 (Hs), Q8R2F2 (Mm), Q564G3 (Rn)

EC number

1.14.-.-

Cofactors

NAD

Comments

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References

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1. Beauchamp E, Tekpli X, Marteil G, Lagadic-Gossmann D, Legrand P, Rioux V. (2009) N-Myristoylation targets dihydroceramide Delta4-desaturase 1 to mitochondria: partial involvement in the apoptotic effect of myristic acid. Biochimie, 91 (11-12): 1411-9. [PMID:19647031]

2. Camacho L, Simbari F, Garrido M, Abad JL, Casas J, Delgado A, Fabriàs G. (2012) 3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate. Bioorg Med Chem, 20 (10): 3173-9. [PMID:22537678]

3. Cingolani F, Casasampere M, Sanllehí P, Casas J, Bujons J, Fabrias G. (2014) Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II. J Lipid Res, 55 (8): 1711-20. [PMID:24875537]

4. Fabrias G, Muñoz-Olaya J, Cingolani F, Signorelli P, Casas J, Gagliostro V, Ghidoni R. (2012) Dihydroceramide desaturase and dihydrosphingolipids: debutant players in the sphingolipid arena. Prog Lipid Res, 51 (2): 82-94. [PMID:22200621]

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.

Sphingolipid Δ4-desaturase C

Overview

Enzymes

Comments

References

How to cite this family page

Sphingolipid Δ⁴-desaturase C