Neutral sphingomyelinase coupling factors | Enzymes | IUPHAR/BPS Guide to MALARIA PHARMACOLOGY

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Neutral sphingomyelinase coupling factors

Neutral sphingomyelinase coupling factors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Protein FAN [1] and polycomb protein EED [3] allow coupling between TNF receptors and neutral sphingomyelinase phosphodiesterases.

Enzymes

embryonic ectoderm development C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2487

Nomenclature

embryonic ectoderm development

Previous and unofficial names

Polycomb protein EED | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1

Genes

EED (Hs), Eed (Mm), Eed (Rn)

Ensembl ID

ENSG00000074266 (Hs), ENSMUSG00000030619 (Mm), ENSRNOG00000017509 (Rn)

UniProtKB AC

O75530 (Hs), Q921E6 (Mm)

Selective inhibitors

A-395 (Binding) pK_i 9.4 [2]

neutral sphingomyelinase activation associated factor C Show summary »« Hide summary

Target Id	2495
Nomenclature	neutral sphingomyelinase activation associated factor
Previous and unofficial names	Factor associated with neutral sphingomyelinase activation \| FAN \| neutral sphingomyelinase (N-SMase) activation associated factor
Genes	NSMAF (Hs), Nsmaf (Mm), Nsmaf (Rn)
Ensembl ID	ENSG00000035681 (Hs), ENSMUSG00000028245 (Mm), ENSRNOG00000010234 (Rn)
UniProtKB AC	Q92636 (Hs), O35242 (Mm)

References

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1. Adam-Klages S, Adam D, Wiegmann K, Struve S, Kolanus W, Schneider-Mergener J, Krönke M. (1996) FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. Cell, 86 (6): 937-47. [PMID:8808629]

2. He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM et al.. (2017) The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol, 13 (4): 389-395. [PMID:28135237]

3. Philipp S, Puchert M, Adam-Klages S, Tchikov V, Winoto-Morbach S, Mathieu S, Deerberg A, Kolker L, Marchesini N, Kabelitz D et al.. (2010) The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase. Proc Natl Acad Sci USA, 107 (3): 1112-7. [PMID:20080539]

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.