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S9: Prolyl oligopeptidase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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This is a family of serine proteases that share the capacity to cleave Xaa-Pro dipeptides from N-termini of their substrates.
DPP4 is a validated drug target with >10 approved DPP4 inhibitors in clinical use for the treatment of type 2 diabetes mellitus, including the orally active drug vildagliptin. DPP8 and DPP9 have been shown participate in multiple biological processes and diseases, including tumour development, immune regulation, the inflammatory response and immune cell pyroptosis, energy metabolism, cell proliferation and apoptosis, cell adhesion and migration, and COVID-19 [4,11-12]. The delevopment of selective DPP8 or DPP9 inhibitors is underway to help differentiate the specific roles of each enzyme in physiological and/or pathological processes [2-3,9-10].

Enzymes

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acylaminoacyl-peptide hydrolase Show summary » More detailed page go icon to follow link

dipeptidyl peptidase 4 C Show summary » More detailed page go icon to follow link

dipeptidyl peptidase 8 Show summary » More detailed page go icon to follow link

dipeptidyl peptidase 9 Show summary » More detailed page go icon to follow link

fibroblast activation protein alpha Show summary » More detailed page go icon to follow link

prolyl endopeptidase Show summary » More detailed page go icon to follow link

prolyl endopeptidase like Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

S9: Prolyl oligopeptidase. Accessed on 29/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=758.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.