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Calcium- and sodium-activated potassium channels (KCa, KNa) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Calcium- and sodium- activated potassium channels are members of the 6TM family of K channels which comprises the voltage-gated KV subfamilies, including the KCNQ subfamily, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 6 or 7TM) and the Ca2+- and Na+-activated SK subfamily (nomenclature as agreed by the NC-IUPHAR Subcommittee on Calcium- and sodium-activated potassium channels [12]). As for the 2TM family, the pore-forming a subunits form tetramers and heteromeric channels may be formed within subfamilies (e.g. KV1.1 with KV1.2; KCNQ2 with KCNQ3).

Channels and Subunits

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KCa1.1 C Show summary » More detailed page go icon to follow link

KCa2.1 C Show summary » More detailed page go icon to follow link

KCa2.2 C Show summary » More detailed page go icon to follow link

KCa2.3 C Show summary » More detailed page go icon to follow link

KCa3.1 C Show summary » More detailed page go icon to follow link

KNa1.1 C Show summary » More detailed page go icon to follow link

KNa1.2 C Show summary » More detailed page go icon to follow link

KCa5.1 C Show summary » More detailed page go icon to follow link

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels. Br J Pharmacol. 178 Suppl 1:S157-S245.