Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)

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Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Type II PIP kinases are essential for the production of the second messenger phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) by phosphorylating PtdIns(5)P [1]. This enzyme family is also known as type II PIP(5)Ks.

Enzymes

PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2858

Nomenclature

phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

Common abbreviation

PIP4K2A

Previous and unofficial names

Genes

PIP4K2A (Hs), Pip4k2a (Mm), Pip4k2a (Rn)

Ensembl ID

ENSG00000150867 (Hs), ENSMUSG00000026737 (Mm), ENSRNOG00000016670 (Rn)

UniProtKB AC

P48426 (Hs), O70172 (Mm), Q9R0I8 (Rn)

EC number

2.7.1.149
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate <=> ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase type 2 beta) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2162

Nomenclature

phosphatidylinositol-5-phosphate 4-kinase type 2 beta

Common abbreviation

PIP4K2B

Previous and unofficial names

Genes

PIP4K2B (Hs), Pip4k2b (Mm), Pip4k2b (Rn)

Ensembl ID

ENSG00000276293 (Hs), ENSMUSG00000018547 (Mm), ENSRNOG00000013030 (Rn)

UniProtKB AC

P78356 (Hs), Q80XI4 (Mm), O88377 (Rn)

EC number

2.7.1.149

PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2163

Nomenclature

phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Common abbreviation

PIP4K2C

Previous and unofficial names

phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | PIP4KII-gamma | PIP5K2C | phosphatidylinositol-5-phosphate 4-kinase, type II, gamma | phosphatidylinositol-5-phosphate 4-kinase

Genes

PIP4K2C (Hs), Pip4k2c (Mm), Pip4k2c (Rn)

Ensembl ID

ENSG00000166908 (Hs), ENSMUSG00000025417 (Mm), ENSRNOG00000005138 (Rn)

UniProtKB AC

Q8TBX8 (Hs), Q91XU3 (Mm), O88370 (Rn)

EC number

2.7.1.149

References

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How to cite this family page

Database page citation:

Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family). Accessed on 11/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=674.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.