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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The LMR kinases are unusual amongst the RTKs in possessing a short extracellular domain and extended intracellular domain (hence the ‘Lemur’ name reflecting the long tail). A precise function for these receptors has yet to be defined, although LMR1 was identified as a potential marker of apoptosis [1], giving rise to the name AATYK (Apoptosis-associated tyrosine kinase); while over-expression induces differentiation in neuroblastoma cells [2].
Lmr1 (apoptosis associated tyrosine kinase) C Show summary » More detailed page |
Lmr2 (lemur tyrosine kinase 2) C Show summary » More detailed page |
Lmr3 (lemur tyrosine kinase 3) C Show summary » More detailed page |
Database page citation:
Type XVIII RTKs: LMR family. Accessed on 07/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=658.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.
As yet no selective inhibitors of the LMR family have been described.