STE11 family

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Targets
Enzymes
Kinases (EC 2.7.x.x)
STE: Homologs of yeast Sterile 7, Sterile 11, Sterile 20 kinases
STE11 family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

MEKK1 (mitogen-activated protein kinase kinase kinase 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2069

Nomenclature

mitogen-activated protein kinase kinase kinase 1

Common abbreviation

MEKK1

Previous and unofficial names

MAPK/ERK kinase kinase 1 | MAPKKK1 | MEK kinase 1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

Genes

MAP3K1 (Hs), Map3k1 (Mm), Map3k1 (Rn)

Ensembl ID

ENSG00000095015 (Hs), ENSMUSG00000021754 (Mm), ENSRNOG00000013177 (Rn)

UniProtKB AC

Q13233 (Hs), P53349 (Mm), Q62925 (Rn)

EC number

2.7.11.25

MEKK2 (mitogen-activated protein kinase kinase kinase 2) Show summary »« Hide summary More detailed page go icon to follow link

MEKK3 (mitogen-activated protein kinase kinase kinase 3) Show summary »« Hide summary More detailed page go icon to follow link

MEKK4 (mitogen-activated protein kinase kinase kinase 4) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2079

Nomenclature

mitogen-activated protein kinase kinase kinase 4

Common abbreviation

MEKK4

Previous and unofficial names

MAP three kinase 1 | MAPK/ERK kinase kinase 4 | MAPKKK4 | MTK1 | RP17 | Tas

Genes

MAP3K4 (Hs), Map3k4 (Mm), Map3k4 (Rn)

Ensembl ID

ENSG00000085511 (Hs), ENSMUSG00000014426 (Mm), ENSRNOG00000017419 (Rn)

UniProtKB AC

Q9Y6R4 (Hs), O08648 (Mm)

EC number

2.7.11.25

ASK1 (mitogen-activated protein kinase kinase kinase 5) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2080

Nomenclature

mitogen-activated protein kinase kinase kinase 5

Common abbreviation

ASK1

Previous and unofficial names

apoptosis signal regulating kinase 1 | ASK1 | MAPK/ERK kinase kinase 5 | MAPKKK5 | MEK kinase 5

Genes

MAP3K5 (Hs), Map3k5 (Mm), Map3k5 (Rn)

Ensembl ID

ENSG00000197442 (Hs), ENSMUSG00000071369 (Mm), ENSRNOG00000031700 (Rn)

UniProtKB AC

Q99683 (Hs), O35099 (Mm)

EC number

2.7.11.25

Inhibitors

compound 10 [PMID: 23147077] pIC₅₀ 8.0 [2]

MSC2032964A pIC₅₀ 7.0 [1]

Comment

ASK1 is a widely expressed redox-sensitive and stress-activated serine threonine kinase that activates p38 and c-Jun N-terminal kinase (JNK) MAP kinases.

MEKK6 (mitogen-activated protein kinase kinase kinase 6) Show summary »« Hide summary More detailed page go icon to follow link

MAP3K15 (mitogen-activated protein kinase kinase kinase 15) Show summary »« Hide summary More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

STE11 family. Accessed on 18/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=621.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.