TAO subfamily

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Kinases (EC 2.7.x.x)
STE: Homologs of yeast Sterile 7, Sterile 11, Sterile 20 kinases
STE20 family
TAO subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The human genome encodes three thousand and one amino acid (TAO) kinase genes. The enzymes regulate MAPK and Hippo signaling pathways and have pleiotropic functions, participating in a range of cellular processes including stress responses, cell proliferation, immune responses and neurodevelopment [1]. Whilst the N-terminal catalytic domains of the three TAOKs are conserved, divergent non-catalytic functions appear to be mediated by regulatory domains in the protein structures, Dysregulated activity has been associated with neurological disorders.

Enzymes

TAO1 (TAO kinase 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2233

Nomenclature

TAO kinase 1

Common abbreviation

TAO1

Previous and unofficial names

Genes

TAOK1 (Hs), Taok1 (Mm), Taok1 (Rn)

Ensembl ID

ENSG00000160551 (Hs), ENSMUSG00000017291 (Mm), ENSRNOG00000015692 (Rn)

UniProtKB AC

Q7L7X3 (Hs), Q5F2E8 (Mm), O88664 (Rn)

EC number

2.7.11.1

TAO2 (TAO kinase 2) Show summary »« Hide summary More detailed page go icon to follow link

TAO3 (TAO kinase 3) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2235

Nomenclature

TAO kinase 3

Common abbreviation

TAO3

Previous and unofficial names

Genes

TAOK3 (Hs), Taok3 (Mm), Taok3 (Rn)

Ensembl ID

ENSG00000135090 (Hs), ENSMUSG00000061288 (Mm), ENSRNOG00000001138 (Rn)

UniProtKB AC

Q9H2K8 (Hs), Q8BYC6 (Mm), Q53UA7 (Rn)

EC number

2.7.11.1

References

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How to cite this family page

Database page citation:

TAO subfamily. Accessed on 25/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=551.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.