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p38 subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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p38 MAP kinase is a ubiquitous, highly conserved enzyme which regulates the production of proinflammatory mediators (such as TNFα and IL-1) in response to inflammatory cytokines or environmental stress [6,12-13]. Four p38 MAP kinase homologs have been identified, as have the upstream and downstream signalling mechanisms and enzyme substrates [5,8,15]. Inhibition of these enzymes reduces inflammatory cytokine synthesis. p38 MAP kinase enzymes are therefore highly pursued drug targets for conditions including inflammation, arthritis and other joint diseases, septic shock, and myocardial injury.

Enzymes

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p38α (mitogen-activated protein kinase 14) Show summary » More detailed page go icon to follow link

p38β (mitogen-activated protein kinase 11) Show summary » More detailed page go icon to follow link

p38γ (mitogen-activated protein kinase 12) Show summary » More detailed page go icon to follow link

p38δ (mitogen-activated protein kinase 13) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

p38 subfamily. Accessed on 11/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=519.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.