CDK8 subfamily

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Kinases (EC 2.7.x.x)
CMGC: Containing CDK, MAPK, GSK3, CLK families
Cyclin-dependent kinase (CDK) family
CDK8 subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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CDK8 and CDK19 act as subunits of mammalian mediator complexes, which are essential regulators of RNA polymerase II transcriptional machinery [1]. CDK8 is also an oncogene and hence a molecular target for the developmet of novel anti-cancer therapeutics [2-4].

Enzymes

CDK8 (cyclin dependent kinase 8) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1980

Nomenclature

cyclin dependent kinase 8

Common abbreviation

CDK8

Previous and unofficial names

Cell division protein kinase 8 | Mediator of RNA polymerase II transcription subunit CDK8 | cyclin-dependent kinase 8

Genes

CDK8 (Hs), Cdk8 (Mm)

Ensembl ID

ENSG00000132964 (Hs), ENSMUSG00000029635 (Mm)

UniProtKB AC

P49336 (Hs), Q8R3L8 (Mm)

EC number

2.7.11.22

2.7.11.23

CDK19 (cyclin dependent kinase 19) Show summary »« Hide summary More detailed page go icon to follow link

References

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1. Conaway RC, Sato S, Tomomori-Sato C, Yao T, Conaway JW. (2005) The mammalian Mediator complex and its role in transcriptional regulation. Trends Biochem Sci, 30 (5): 250-5. [PMID:15896743]

2. Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S et al.. (2008) CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature, 455 (7212): 547-51. [PMID:18794900]

3. Firestein R, Hahn WC. (2009) Revving the Throttle on an oncogene: CDK8 takes the driver seat. Cancer Res, 69 (20): 7899-901. [PMID:19808961]

4. Seo JO, Han SI, Lim SC. (2010) Role of CDK8 and beta-catenin in colorectal adenocarcinoma. Oncol Rep, 24 (1): 285-91. [PMID:20514474]

How to cite this family page

Database page citation:

CDK8 subfamily. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=497.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.