A mouse stromal cell cDNA library was used to clone C2.3 [2], later termed Rag1-activating protein 1, with a sequence homology predictive of a 4TM topology. The plant orthologues, termed SWEETs, appear to be 7 TM proteins, with extracellular N-termini, and the capacity for bidirectional flux of D-glucose [1]. Expression of mouse SWEET in the mammary gland was suggestive of a role in Golgi lactose synthesis [1].

* Key recommended reading is highlighted with an asterisk

* Wright EM. (2013) Glucose transport families SLC5 and SLC50. Mol Aspects Med, 34 (2-3): 183-96. [PMID:23506865]

* Wright EM, Loo DD, Hirayama BA. (2011) Biology of human sodium glucose transporters. Physiol Rev, 91 (2): 733-94. [PMID:21527736]

1. Chen LQ, Hou BH, Lalonde S, Takanaga H, Hartung ML, Qu XQ, Guo WJ, Kim JG, Underwood W, Chaudhuri B et al.. (2010) Sugar transporters for intercellular exchange and nutrition of pathogens. Nature, 468 (7323): 527-32. [PMID:21107422]

2. Tagoh H, Kishi H, Muraguchi A. (1996) Molecular cloning and characterization of a novel stromal cell-derived cDNA encoding a protein that facilitates gene activation of recombination activating gene (RAG)-1 in human lymphoid progenitors. Biochem Biophys Res Commun, 221 (3): 744-9. [PMID:8630032]