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Protein kinase C (PKC) family C

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Overview

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Protein kinase C is the target for the tumour-promoting phorbol esters, such as tetradecanoyl-β-phorbol acetate (TPA, also known as phorbol 12-myristate 13-acetate). Subfamilies of protein kinase C are identified on the basis of sequence similarities, although functional division into the groups of classical protein kinase C isoforms (PKCα, PKCβ, and PKCγ) activated by Ca2+ and diacylglycerol, novel protein kinase C isoforms (PKCδ, PKCε, PKCη, and PKCθ) activated by diacylglycerol and atypical protein kinase C isoforms (PKCι and PKCζ) are useful.

Subfamilies

The Kinome image shown here was obtained from Chartier et al. (2013, <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740139/figure/fig-4/' target='_blank'>Figure 4</a>) <a href='https://www.ncbi.nlm.nih.gov/pubmed/23940838' target='_blank'>https://www.ncbi.nlm.nih.gov/pubmed/23940838</a> and has been annotated to show the kinases that are targeted by currently approved kinase inhibitor drugs (last updated in April 2018).

Further reading

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How to cite this family page

Database page citation:

Protein kinase C (PKC) family. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=286.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.