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Inositol polyphosphate phosphatases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of this family exhibit phosphatase activity towards IP3, as well as towards other inositol derivatives, including the phospholipids PIP2 and PIP3. With IP3 as substrate, 1-phosphatase (EC 3.1.3.57) generates 4,5,-IP2, 4-phosphatases (EC 3.1.3.66, ENSFM00250000001432) generate 1,5,-IP2 and 5-phosphatases (E.C. 3.1.3.36 or 3.1.3.56) generate 1,4,-IP2.

Enzymes

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INPP1 Show summary »

INPP4A Show summary »

INPP4B Show summary »

INPP5A Show summary »

INPP5B Show summary »

SHIP1 (INPP5D) Show summary » More detailed page go icon to follow link

INPP5E Show summary »

INPP5J Show summary »

INPP5K Show summary »

INPPL1 Show summary »

OCRL Show summary »

SYNJ1 Show summary »

SYNJ2 Show summary »

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References

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How to cite this family page

Database page citation:

Inositol polyphosphate phosphatases. Accessed on 25/09/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=281.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.