Top ▲

Adhesion Class GPCRs C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide More detailed introduction go icon to follow link

Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a GPCR autoproteolysis-inducing (GAIN) domain [3] containing a GPCR proteolysis site (GPS). The N-terminal extracellular region often shares structural homology with adhesive domains (e.g. cadherins, immunolobulin, lectins) facilitating inter- and matricellular interactions and leading to the term adhesion GPCR [29,116]. Several receptors have been suggested to function as mechanosensors [12,71,87,110]. Cryo-EM structures of the 7-transmembrane domain of several adhesion GPCRs have been determined recently [5,53,73-74,80-81,112,120]. The nomenclature of these receptors was revised in 2015 as recommended by NC-IUPHAR and the Adhesion GPCR Consortium [33].

Receptors

Click here for help

ADGRA1 C Show summary » More detailed page go icon to follow link

ADGRA2 C Show summary » More detailed page go icon to follow link

ADGRA3 C Show summary » More detailed page go icon to follow link

ADGRB1 C Show summary » More detailed page go icon to follow link

ADGRB2 C Show summary » More detailed page go icon to follow link

ADGRB3 C Show summary » More detailed page go icon to follow link

CELSR1 / ADGRC1 C Show summary » More detailed page go icon to follow link

CELSR2 / ADGRC2 C Show summary » More detailed page go icon to follow link

CELSR3 / ADGRC3 C Show summary » More detailed page go icon to follow link

ADGRD1 C Show summary » More detailed page go icon to follow link

ADGRD2 C Show summary » More detailed page go icon to follow link

ADGRE1 C Show summary » More detailed page go icon to follow link

ADGRE2 C Show summary » More detailed page go icon to follow link

ADGRE3 C Show summary » More detailed page go icon to follow link

ADGRE4P C Show summary » More detailed page go icon to follow link

ADGRE5 C Show summary » More detailed page go icon to follow link

ADGRF1 C Show summary » More detailed page go icon to follow link

ADGRF2 C Show summary » More detailed page go icon to follow link

ADGRF3 C Show summary » More detailed page go icon to follow link

ADGRF4 C Show summary » More detailed page go icon to follow link

ADGRF5 C Show summary » More detailed page go icon to follow link

ADGRG1 C Show summary » More detailed page go icon to follow link

ADGRG2 C Show summary » More detailed page go icon to follow link

ADGRG3 C Show summary » More detailed page go icon to follow link

ADGRG4 C Show summary » More detailed page go icon to follow link

ADGRG5 C Show summary » More detailed page go icon to follow link

ADGRG6 C Show summary » More detailed page go icon to follow link

ADGRG7 C Show summary » More detailed page go icon to follow link

ADGRL1 C Show summary » More detailed page go icon to follow link

ADGRL2 C Show summary » More detailed page go icon to follow link

ADGRL3 C Show summary » More detailed page go icon to follow link

ADGRL4 C Show summary » More detailed page go icon to follow link

ADGRV1 C Show summary » More detailed page go icon to follow link

Further reading

Click here for help

Show »

References

Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. Br J Pharmacol. 180 Suppl 2:S23-S144.