F-type ATPase | Transporters | IUPHAR/BPS Guide to MALARIA PHARMACOLOGY

F-type ATPase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The F-type ATPase, also known as ATP synthase or ATP phosphohydrolase (H⁺-transporting), is a mitochondrial membrane-associated multimeric complex consisting of two domains, an F₀ channel domain in the membrane and an F₁ domain extending into the lumen. Proton transport across the inner mitochondrial membrane is used to drive the synthesis of ATP, although it is also possible for the enzyme to function as an ATPase. The ATP5O subunit (oligomycin sensitivity-conferring protein, OSCP, (P48047)), acts as a connector between F₁ and F₀ motors.

The F₁ motor, responsible for ATP turnover, has the subunit composition α3β3γδε.

The F₀ motor, responsible for ion translocation, is complex in mammals, with probably nine subunits centring on A, B, and C subunits in the membrane, together with D, E, F2, F6, G2 and 8 subunits. Multiple pseudogenes for the F₀ motor proteins have been defined in the human genome.

Transporters

F-type ATPase α subunit Show summary »« Hide summary

Target Id	796
Nomenclature	F-type ATPase α subunit
Previous and unofficial names	ATP5A \| ATP5AL2 \| ATPM \| OMR \| ORM \| ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle \| ATP synthase subunit alpha, mitochondrial \| mitochondrial H+-ATP synthase alpha subunit \| Mom2 \| ATP5A1 \| ATP synthase, H transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle \| ATP synthase \| ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 \| Atp5a1
Genes	ATP5F1A (Hs), Atp5f1a (Mm), Atp5f1a (Rn)
Ensembl ID	ENSG00000152234 (Hs), ENSMUSG00000025428 (Mm), ENSRNOG00000017032 (Rn)
UniProtKB AC	P25705 (Hs), Q03265 (Mm), P15999 (Rn)

F-type ATPase β subunit Show summary »« Hide summary

Target Id	797
Nomenclature	F-type ATPase β subunit
Previous and unofficial names	ATPSB \| ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit \| mitochondrial ATP synthase beta subunit \| ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide \| ATP synthase, H transporting, mitochondrial F1 complex, beta polypeptide \| ATP synthase \| ATP5B \| Atp5b
Genes	ATP5F1B (Hs), Atp5f1b (Mm), Atp5f1b (Rn)
Ensembl ID	ENSG00000110955 (Hs), ENSMUSG00000025393 (Mm), ENSRNOG00000002840 (Rn)
UniProtKB AC	P06576 (Hs), P56480 (Mm), P10719 (Rn)

F-type ATPase γ subunit Show summary »« Hide summary

Target Id	798
Nomenclature	F-type ATPase γ subunit
Previous and unofficial names	ATP5C \| ATP5CL1 \| ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 \| F-ATPase gamma subunit \| ATP synthase, H transporting, mitochondrial F1 complex, gamma polypeptide 1 \| ATP synthase \| ATP5C1 \| Atp5c1
Genes	ATP5F1C (Hs), Atp5f1c (Mm), Atp5f1c (Rn)
Ensembl ID	ENSG00000165629 (Hs), ENSMUSG00000025781 (Mm), ENSRNOG00000019223 (Rn)
UniProtKB AC	P36542 (Hs), Q91VR2 (Mm), P35435 (Rn)

F-type ATPase δ subunit Show summary »« Hide summary

Target Id	799
Nomenclature	F-type ATPase δ subunit
Previous and unofficial names	ATP synthase subunit delta, mitochondrial \| ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit \| F-ATPase delta subunit \| ATP synthase, H transporting, mitochondrial F1 complex, delta subunit \| ATP synthase \| ATP5D \| Atp5d
Genes	ATP5F1D (Hs), Atp5f1d (Mm), Atp5f1d (Rn)
Ensembl ID	ENSG00000099624 (Hs), ENSMUSG00000003072 (Mm), ENSRNOG00000014625 (Rn)
UniProtKB AC	P30049 (Hs), Q9D3D9 (Mm), P35434 (Rn)

F-type ATPase ε subunit Show summary »« Hide summary

Target Id	800
Nomenclature	F-type ATPase ε subunit
Previous and unofficial names	ATP synthase subunit epsilon, mitochondrial \| ATPase subunit epsilon \| ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit \| ATP synthase, H transporting, mitochondrial F1 complex, epsilon subunit \| ATP synthase \| ATP5E \| Atp5e
Genes	ATP5F1E (Hs), Atp5f1e (Mm), Atp5f1e (Rn)
Ensembl ID	ENSG00000124172 (Hs), ENSMUSG00000016252 (Mm), ENSRNOG00000049912 (Rn)
UniProtKB AC	P56381 (Hs), P56382 (Mm), P29418 (Rn)

F-type ATPase A subunit Show summary »« Hide summary

Target Id	801
Nomenclature	F-type ATPase A subunit
Previous and unofficial names	F-ATPase protein 6 \| ATP6 \| ATPase-6 \| MTATP6 \| RP \| Su6m \| spicular retinitis pigmentosa with dementia, seizures, ataxia, proximal muscle weakness and sensory deficit \| ATP synthase 6, mitochondrial \| ATP synthase F0 subunit 6 \| ATPase subunit 6 \| ATPASE6 \| mitochondrially encoded ATP synthase 6
Genes	MT-ATP6 (Hs), mt-Atp6 (Mm), Mt-atp6 (Rn)
Ensembl ID	ENSG00000198899 (Hs), ENSMUSG00000064357 (Mm), ENSRNOG00000031979 (Rn)
UniProtKB AC	P00846 (Hs), P00848 (Mm), P05504 (Rn)

F-type ATPase B subunit Show summary »« Hide summary

Target Id	802
Nomenclature	F-type ATPase B subunit
Previous and unofficial names	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 \| ATP synthase subunit b, mitochondrial \| ATPase subunit b \| C76477 \| ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 \| ATP synthase, H transporting, mitochondrial Fo complex, subunit B1 \| ATP synthase \| ATP5F1 \| ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 \| Atp5f1
Genes	ATP5PB (Hs), Atp5pb (Mm), Atp5pb (Rn)
Ensembl ID	ENSG00000116459 (Hs), ENSMUSG00000000563 (Mm), ENSRNOG00000064742 (Rn)
UniProtKB AC	P24539 (Hs), Q9CQQ7 (Mm), P19511 (Rn)

F-type ATPase C subunit Show summary »« Hide summary

Target Id	803
Nomenclature	F-type ATPase C subunit
Previous and unofficial names	ATP5G \| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) isoform 3 \| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 2 \| ATP synthase H+ transporting mitochondrial F0 complex subunit c (subunit 9) isoform 1 \| ATP synthase lipid-binding protein, mitochondrial \| ATP synthase proteolipid P1 \| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 \| ATPase protein 9 \| ATPase subunit c \| ATP synthase proteolipid P2 \| ATP synthase proteolipid P3 \| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9) \| ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) \| ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) \| ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) \| ATP synthase, H transporting, mitochondrial Fo complex, subunit C2 (subunit 9) \| ATP synthase, H transporting, mitochondrial Fo complex, subunit C1 (subunit 9) \| ATP synthase, H transporting, mitochondrial Fo complex, subunit C3 (subunit 9) \| ATP synthase \| ATP5G1 \| ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) \| ATP5G2 \| ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) \| ATP5G3 \| ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) \| Atp5g1 \| Atp5g2 \| Atp5g3
Genes	ATP5MC1 (Hs), ATP5MC2 (Hs), ATP5MC3 (Hs), Atp5mc1 (Mm), Atp5mc2 (Mm), Atp5mc3 (Mm), Atp5mc1 (Rn), Atp5mc2 (Rn), Atp5mc3 (Rn)
Ensembl ID	ENSG00000135390 (Hs), ENSG00000154518 (Hs), ENSG00000159199 (Hs), ENSMUSG00000006057 (Mm), ENSMUSG00000018770 (Mm), ENSMUSG00000062683 (Mm), ENSRNOG00000001596 (Rn), ENSRNOG00000007235 (Rn), ENSRNOG00000015320 (Rn), ENSRNOG00000069121 (Rn)
UniProtKB AC	P05496 (Hs), P48201 (Hs), Q06055 (Hs), P56383 (Mm), P56384 (Mm), Q9CR84 (Mm), Q06645 (Rn), Q06646 (Rn), Q71S46 (Rn)

F-type ATPase D subunit Show summary »« Hide summary

Target Id	804
Nomenclature	F-type ATPase D subunit
Previous and unofficial names	ATP5JD \| ATPQ \| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d \| ATP synthase subunit d, mitochondrial \| ATPase subunit d \| ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d \| ATP synthase, H transporting, mitochondrial Fo complex, subunit d \| ATP synthase \| ATP5H \| ATP synthase, H+ transporting, mitochondrial Fo complex subunit D \| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D \| Atp5h
Genes	ATP5PD (Hs), Atp5pd (Mm), Atp5pd (Rn)
Ensembl ID	ENSG00000167863 (Hs), ENSMUSG00000034566 (Mm), ENSRNOG00000003626 (Rn)
UniProtKB AC	O75947 (Hs), Q9DCX2 (Mm), P31399 (Rn)

F-type ATPase E subunit Show summary »« Hide summary

Target Id	805
Nomenclature	F-type ATPase E subunit
Previous and unofficial names	ATP5K \| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit e \| ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e \| ATPase subunit e \| Lfm1 \| ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E \| ATP synthase, H transporting, mitochondrial Fo complex, subunit E \| ATP synthase \| ATP5I \| ATP synthase, H+ transporting, mitochondrial Fo complex subunit E \| ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit E \| Atp5i \| Atp5k
Genes	ATP5ME (Hs), Atp5me (Mm), Atp5me (Rn)
Ensembl ID	ENSG00000169020 (Hs), ENSMUSG00000050856 (Mm), ENSRNOG00000000064 (Rn)
UniProtKB AC	P56385 (Hs), Q06185 (Mm), P29419 (Rn)

F-type ATPase F2 subunit Show summary »« Hide summary

Target Id	806
Nomenclature	F-type ATPase F2 subunit
Previous and unofficial names	ATP5JL \| F1Fo-ATPase \| ATP synthase f chain, mitochondrial \| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2 \| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2 \| F1Fo-ATP synthase complex Fo membrane domain f subunit \| F1Fo-ATPase synthase f subunit \| ATP synthase subunit f, mitochondrial \| ATP synthase, H transporting, mitochondrial Fo complex, subunit F2 \| ATP synthase \| ATP5J2 \| ATP synthase, H+ transporting, mitochondrial Fo complex subunit F2 \| Atp5j2
Genes	ATP5MF (Hs), Atp5mf (Mm), Atp5mf (Rn)
Ensembl ID	ENSG00000241468 (Hs), ENSMUSG00000038690 (Mm), ENSRNOG00000027049 (Rn)
UniProtKB AC	P56134 (Hs), P56135 (Mm), D3ZAF6 (Rn)

F-type ATPase F6 subunit Show summary »« Hide summary

Target Id	807
Nomenclature	F-type ATPase F6 subunit
Previous and unofficial names	ATP5 \| ATP5A \| ATPM \| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6 \| coupling factor 6 \| ATP synthase-coupling factor 6, mitochondrial \| ATPase subunit F6 \| CF6 \| ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 \| ATP synthase, H transporting, mitochondrial Fo complex, subunit F6 \| ATP synthase \| ATP5J \| ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 \| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F \| Atp5j
Genes	ATP5PF (Hs), Atp5pf (Mm), Atp5pf (Rn)
Ensembl ID	ENSG00000154723 (Hs), ENSMUSG00000022890 (Mm), ENSRNOG00000001551 (Rn)
UniProtKB AC	P18859 (Hs), P97450 (Mm), P21571 (Rn)

F-type ATPase G2 subunit Show summary »« Hide summary

Target Id	808
Nomenclature	F-type ATPase G2 subunit
Previous and unofficial names	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g, isoform 2 \| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G2 \| ATP synthase, H+ transporting, mitochondrial F1F0, subunit g \| ATP5K2 \| Atp5l2 \| ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2 \| ATP5L2 \| ATP synthase, H+ transporting, mitochondrial Fo complex subunit G2 \| ATP synthase, H+ transporting, mitochondrial FO complex, subunit G2, pseudogene \| ATP synthase
Genes	ATP5MGL (Hs), Atp5l2-ps (Mm)
Ensembl ID	ENSG00000249222 (Hs), ENSMUSG00000084168 (Mm)
UniProtKB AC	Q7Z4Y8 (Hs)

F-type ATPase 8 subunit Show summary »« Hide summary

Target Id	809
Nomenclature	F-type ATPase 8 subunit
Previous and unofficial names	A6L \| ATP synthase 8, mitochondrial \| ATP synthase F0 subunit 8 \| ATPase subunit 8 \| URFA6L \| ATP8 \| MTATP8 \| mitochondrially encoded ATP synthase 8
Genes	MT-ATP8 (Hs), mt-Atp8 (Mm), Mt-atp8 (Rn)
Ensembl ID	ENSG00000228253 (Hs), ENSMUSG00000064356 (Mm), ENSRNOG00000033299 (Rn)
UniProtKB AC	P03928 (Hs), P03930 (Mm), P11608 (Rn)

How to cite this family page

Database page citation:

F-type ATPase. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=156.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.