Dual specificity phosphatases

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Class I classical (Cys-based) phosphatases
Dual specificity phosphatases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Dual-specificity phosphatases can dephosphorylate tyrosine or serine/threonine residues.

Enzymes

protein tyrosine phosphatase 4A3 Show summary »« Hide summary

Target Id

3224

Nomenclature

protein tyrosine phosphatase 4A3

Previous and unofficial names

PRL-3 | PRL3

Genes

PTP4A3 (Hs), Ptp4a3 (Mm), Ptp4a3 (Rn)

Ensembl ID

ENSG00000184489 (Hs), ENSMUSG00000059895 (Mm), ENSRNOG00000007628 (Rn)

UniProtKB AC

O75365 (Hs), Q9CTC8 (Mm)

EC number

3.1.3.48

Inhibitors

JMS-053 pIC₅₀ 7.7 [2]

Comment

PTP4A3 directly dephosphorylates SHP-2 phosphatase and p38 kinase. Its inhibition disrupts STAT3 and p38 signaling in ovarian cancer cells [1].

References

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How to cite this family page

Database page citation:

Dual specificity phosphatases. Accessed on 18/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1077.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.