Dual specificity phosphatases

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Class I classical (Cys-based) phosphatases
Dual specificity phosphatases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Dual-specificity phosphatases can dephosphorylate tyrosine or serine/threonine residues.

Enzymes

protein tyrosine phosphatase 4A3 Show summary »« Hide summary

Target Id

3224

Nomenclature

protein tyrosine phosphatase 4A3

Previous and unofficial names

PRL-3 | PRL3

Genes

PTP4A3 (Hs), Ptp4a3 (Mm), Ptp4a3 (Rn)

Ensembl ID

ENSG00000184489 (Hs), ENSMUSG00000059895 (Mm), ENSRNOG00000007628 (Rn)

UniProtKB AC

O75365 (Hs), Q9CTC8 (Mm)

EC number

3.1.3.48

Inhibitors

JMS-053 pIC₅₀ 7.7 [2]

Comment

PTP4A3 directly dephosphorylates SHP-2 phosphatase and p38 kinase. Its inhibition disrupts STAT3 and p38 signaling in ovarian cancer cells [1].

References

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How to cite this family page

Database page citation:

Dual specificity phosphatases. Accessed on 02/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1077.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.