Rho GEFs

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Guanine nucleotide exchange factors (GEFs)
Rho GEFs

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Targets

SOS Ras/Rac guanine nucleotide exchange factor 1 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3096
Nomenclature	SOS Ras/Rac guanine nucleotide exchange factor 1
Previous and unofficial names	GF1 \| gingival fibromatosis, hereditary, 1 (GINGF) \| HGF \| son of sevenless homolog 1 (Drosophila) \| SOS-1
Genes	SOS1 (Hs), Sos1 (Mm), Sos1 (Rn)
Ensembl ID	ENSG00000115904 (Hs), ENSMUSG00000024241 (Mm), ENSRNOG00000007106 (Rn)
UniProtKB AC	Q07889 (Hs), Q62245 (Mm)
Comment	SOS1 regulates the KRAS GDP-GTP cycle. It is required for nucleotide exchange and formation of 'active' GTP-bound KRAS.

vav guanine nucleotide exchange factor 1 Show summary »« Hide summary

Target Id

3338

Nomenclature

vav guanine nucleotide exchange factor 1

Previous and unofficial names

vav 1 guanine nucleotide exchange factor | vav 1 oncogen

Genes

VAV1 (Hs), Vav1 (Mm), Vav1 (Rn)

Ensembl ID

ENSG00000141968 (Hs), ENSMUSG00000034116 (Mm), ENSRNOG00000050430 (Rn)

UniProtKB AC

P15498 (Hs), P27870 (Mm), P54100 (Rn)

Ligands

MRT-6160 (Binding) (Molecular glue degrader) [2]

NGT-201-12 (Binding) (Molecular glue degrader) [1]

Comment

The VAV1 protein is a hematopoietic-specific signaling protein that plays key regulatory functions in immune cell development and function. It acts as a guanine nucleotide exchange factor (GEF) for Rho/Rac family GTPases and as an adaptor/scaffold protein. Dysregulated VAV1 activity has been linked to hematological malignancies (e.g., T-cell lymphomas) and autoimmune diseases and it is therefore being pursued as a therapeutic target. Targeted degradation of VAV1 protein modulates both T- and B-cell receptor-mediated activity in vitro and in vivo, and disrupts cytokine secretion and immune signaling [2].

References

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How to cite this family page

Database page citation:

Rho GEFs. Accessed on 01/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1025.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Cidlowski JA, Davenport AP, Fabbro D, Spedding M, Striessnig J, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets. Br J Pharmacol. 182: S1-S23.