SLC64 Golgi Ca<sup>2+</sup>/H<sup>+</sup> exchangers | Transporters

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SLC superfamily of solute carriers
SLC64 Golgi Ca²⁺/H⁺ exchangers

SLC64 Golgi Ca²⁺/H⁺ exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

transmembrane protein 165 / SLC64A1 C Show summary »« Hide summary

Target Id

3050

Nomenclature

transmembrane protein 165

Systematic nomenclature

SLC64A1

Previous and unofficial names

GDT1 | TMPT27 | TPARL | Ft27 [1]

Genes

TMEM165 (Hs), Tmem165 (Mm), Tmem165 (Rn)

Ensembl ID

ENSG00000134851 (Hs), ENSMUSG00000029234 (Mm), ENSRNOG00000002199 (Rn)

UniProtKB AC

Q9HC07 (Hs), P52875 (Mm), Q4V899 (Rn)

RESOLUTE

TMEM165 (Hs)

Transport type

Exchanger/ Ca²⁺:H⁺

Substrates

Ca²⁺, H⁺ [2]

Mn²⁺ [4-5]

Comment

TMEM165/SLC64 is a putative 6TM intracellular membrane protein. Mutations in the protein are associated with congenital disorder of glycosylation. It has been suggested to be essential for milk production in the mammary gland [6]. TMEM165 deficiency (via siRNA knockdown) causes Golgi glycosylation defects in transfected HEK cells [3].

References

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1. Akagi J, Nomiyama H, Setoyama C, Shimada K, Akagi M. (1988) Messenger RNA expressed in mouse teratocarcinoma stem cells and down-regulated by a tumor-promoting phorbol ester codes for a novel transmembrane protein. Biochem Biophys Res Commun, 157 (2): 548-57. [PMID:3202867]

2. Demaegd D, Foulquier F, Colinet AS, Gremillon L, Legrand D, Mariot P, Peiter E, Van Schaftingen E, Matthijs G, Morsomme P. (2013) Newly characterized Golgi-localized family of proteins is involved in calcium and pH homeostasis in yeast and human cells. Proc Natl Acad Sci USA, 110 (17): 6859-64. [PMID:23569283]

3. Foulquier F, Amyere M, Jaeken J, Zeevaert R, Schollen E, Race V, Bammens R, Morelle W, Rosnoblet C, Legrand D et al.. (2012) TMEM165 deficiency causes a congenital disorder of glycosylation. Am J Hum Genet, 91 (1): 15-26. [PMID:22683087]

4. Potelle S, Dulary E, Climer L, Duvet S, Morelle W, Vicogne D, Lebredonchel E, Houdou M, Spriet C, Krzewinski-Recchi MA et al.. (2017) Manganese-induced turnover of TMEM165. Biochem J, 474 (9): 1481-1493. [PMID:28270545]

5. Potelle S, Morelle W, Dulary E, Duvet S, Vicogne D, Spriet C, Krzewinski-Recchi MA, Morsomme P, Jaeken J, Matthijs G et al.. (2016) Glycosylation abnormalities in Gdt1p/TMEM165 deficient cells result from a defect in Golgi manganese homeostasis. Hum Mol Genet, 25 (8): 1489-500. [PMID:27008884]

6. Snyder NA, Palmer MV, Reinhardt TA, Cunningham KW. (2019) Milk biosynthesis requires the Golgi cation exchanger TMEM165. J Biol Chem, 294 (9): 3181-3191. [PMID:30622138]

How to cite this family page

Database page citation:

SLC64 Golgi Ca²⁺/H⁺ exchangers. Accessed on 30/06/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1016.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.

SLC64 Golgi Ca2+/H+ exchangers C

Transporters

Further reading

References

How to cite this family page

SLC64 Golgi Ca²⁺/H⁺ exchangers C