Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	605	11q23.3	USP2	ubiquitin specific peptidase 2
Mouse	-	613	9 A5.1	Usp2	ubiquitin specific peptidase 2
Rat	-	618	8q22	Usp2	ubiquitin specific peptidase 2

Previous and Unofficial Names

41 kDa ubiquitin-specific protease | deubiquitinating enzyme 2 | ubiquitin carboxyl-terminal hydrolase 2 | ubiquitin specific protease 2 | ubiquitin thioesterase 2 | ubiquitin thiolesterase 2 | ubiquitin-specific-processing protease testis | Ubp41 | UBP-t

Database Links
Specialist databases
MEROPS	C19.013 (Hs)
Other databases
Alphafold	O75604 (Hs), O88623 (Mm), Q5U349 (Rn)
BRENDA	3.4.19.12
ChEMBL Target	CHEMBL1293227 (Hs)
Ensembl Gene	ENSG00000036672 (Hs), ENSMUSG00000032010 (Mm), ENSRNOG00000006663 (Rn)
Entrez Gene	9099 (Hs), 53376 (Mm), 115771 (Rn)
Human Protein Atlas	ENSG00000036672 (Hs)
KEGG Enzyme	3.4.19.12
KEGG Gene	hsa:9099 (Hs), mmu:53376 (Mm), rno:115771 (Rn)
OMIM	604725 (Hs)
Pharos	O75604 (Hs)
RefSeq Nucleotide	NM_171997 (Hs), NM_004205 (Hs), NM_001243759 (Hs), NM_198092 (Mm), NM_016808 (Mm), NM_198091 (Mm), NM_053774 (Rn)
RefSeq Protein	NP_741994 (Hs), NP_004196 (Hs), NP_001230688 (Hs), NP_932759 (Mm), NP_932760 (Mm), NP_058088 (Mm), NP_446226 (Rn)
UniProtKB	O75604 (Hs), O88623 (Mm), Q5U349 (Rn)
Wikipedia	USP2 (Hs)

Enzyme Reaction
EC Number: 3.4.19.12

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference ML364 Hs Inhibition 5.3 pKd 1 ⤷ pKd 5.3 (Kd 5.2x10-6 M) [1] Description: Binding affinity for hUSP2 ML364 Hs Inhibition 6.0 pIC50 1 ⤷ pIC50 6.0 (IC50 1.1x10-6 M) [1] Description: Inhibition of USP2 de-ubiquitinating activity in vitro MS102 Hs Inhibition - - 1 ⤷ [1]