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coenzyme Q8B

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Target id: 1928

Nomenclature: coenzyme Q8B

Abbreviated Name: ADCK4

Family: ABC1-B subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 544 19q13.2 COQ8B coenzyme Q8B
Mouse 1 533 7 A3 Coq8b coenzyme Q8B
Rat 1 528 1q21 Coq8b coenzyme Q8B
Previous and Unofficial Names Click here for help
COQ8 | Adck4 | ADCK4 | aarF domain containing kinase 4
Database Links Click here for help
Alphafold Q96D53 (Hs), Q566J8 (Mm), Q6AY19 (Rn)
BRENDA 2.7.11.-
ChEMBL Target CHEMBL5753 (Hs)
Ensembl Gene ENSG00000123815 (Hs), ENSMUSG00000003762 (Mm), ENSRNOG00000020848 (Rn)
Entrez Gene 79934 (Hs), 76889 (Mm), 308453 (Rn)
Human Protein Atlas ENSG00000123815 (Hs)
KEGG Enzyme 2.7.11.-
KEGG Gene hsa:79934 (Hs), mmu:76889 (Mm), rno:308453 (Rn)
OMIM 615567 (Hs)
Orphanet ORPHA376599 (Hs)
Pharos Q96D53 (Hs)
RefSeq Nucleotide NM_024876 (Hs), NM_133770 (Mm), NM_001012065 (Rn)
RefSeq Protein NP_079152 (Hs), NP_598531 (Mm), NP_001012065 (Rn)
UniProtKB Q96D53 (Hs), Q566J8 (Mm), Q6AY19 (Rn)
Wikipedia COQ8B (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.-
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: ADCK4
Ligand Sp. Type Action Value Parameter
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.6 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 7.2 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.0 pKd
fedratinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.5 pKd
crizotinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.0 pKd
TG-100-115 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.8 pKd
vandetanib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 5.8 pKd
erlotinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 5.6 pKd
BMS-387032 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.5 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
Disease Ontology: DOID:93213
Disease:  Nephrotic syndrome, type 9; NPHS9
OMIM: 615573

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

ABC1-B subfamily: coenzyme Q8B. Last modified on 24/03/2015. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1928.