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Carboxypeptidase B2 (plasma)

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Target id: 1594

Nomenclature: Carboxypeptidase B2 (plasma)

Family: M14: Carboxypeptidase A

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 423 13q14.13 CPB2 carboxypeptidase B2
Mouse - 422 14 D3 Cpb2 carboxypeptidase B2
Rat - 422 15q11 Cpb2 carboxypeptidase B2
Previous and Unofficial Names Click here for help
CPU | PCPB | TAFI | carboxypeptidase B2 (plasma, carboxypeptidase U) | carboxypeptidase R | thrombin-activatable fibrinolysis inhibitor | CPR | carboxypeptidase B2 (plasma)
Database Links Click here for help
Specialist databases
MEROPS M14.009 (Hs)
Other databases
Alphafold Q96IY4 (Hs), Q9JHH6 (Mm), Q9EQV9 (Rn)
BRENDA 3.4.17.20
CATH/Gene3D 3.30.70.340
ChEMBL Target CHEMBL3419 (Hs), CHEMBL4879512 (Rn)
Ensembl Gene ENSG00000080618 (Hs), ENSMUSG00000021999 (Mm), ENSRNOG00000010935 (Rn)
Entrez Gene 1361 (Hs), 56373 (Mm), 113936 (Rn)
Human Protein Atlas ENSG00000080618 (Hs)
KEGG Enzyme 3.4.17.20
KEGG Gene hsa:1361 (Hs), mmu:56373 (Mm), rno:113936 (Rn)
OMIM 603101 (Hs)
Pharos Q96IY4 (Hs)
RefSeq Nucleotide NM_001872 (Hs), NM_019775 (Mm), NM_053617 (Rn)
RefSeq Protein NP_001863 (Hs), NP_062749 (Mm), NP_446069 (Rn)
UniProtKB Q96IY4 (Hs), Q9JHH6 (Mm), Q9EQV9 (Rn)
Wikipedia CPB2 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.17.20

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 4 [PMID: 19954973] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.5 pKi 3
⤷ pKi 8.5 (Ki 3.5x10-9 M) [3]
SQ-24,798 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.4 pKi 2
⤷ pKi 8.4 (Ki 4x10-9 M) [2]
UK-396,082 Small molecule or natural product Primary target of this compound Ligand has a PDB structure Hs Inhibition 8.0 pKi 2
⤷ pKi 8.0 (Ki 1x10-8 M) [2]
compound 3 [PMID: 14640538] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.7 pIC50 1
⤷ pIC50 6.7 (IC50 2x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Immune regulation

References

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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem, 46 (25): 5294-7. [PMID:14640538]

2. Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K et al.. (2007) Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem, 50 (24): 6095-103. [PMID:17990866]

3. Owen DR, Bull DJ, Bunnage ME, Glossop MS, Maguire RJ, Strang RS. (2010) Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor. Bioorg Med Chem Lett, 20 (1): 92-6. [PMID:19954973]

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase B2 (plasma). Last modified on 29/07/2015. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1594.