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L-Aromatic amino-acid decarboxylase

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Target id: 1271

Nomenclature: L-Aromatic amino-acid decarboxylase

Abbreviated Name: AADC

Family: Decarboxylases, Catecholamine turnover

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 480 7p12.2-p12.1 DDC dopa decarboxylase
Mouse - 480 11 7.09 cM Ddc dopa decarboxylase
Rat - 480 14q21 Ddc dopa decarboxylase
Previous and Unofficial Names Click here for help
5-hydroxytryptophan decarboxylase | DOPA decarboxylase | L-Dopa decarboxylase | dopa decarboxylase (aromatic L-amino acid decarboxylase)
Database Links Click here for help
Alphafold P20711 (Hs), O88533 (Mm), P14173 (Rn)
BRENDA 4.1.1.28
CATH/Gene3D 3.90.1150.10, 3.40.640.10
ChEMBL Target CHEMBL1843 (Hs), CHEMBL4230 (Mm)
DrugBank Target P20711 (Hs)
Ensembl Gene ENSG00000132437 (Hs), ENSMUSG00000020182 (Mm), ENSRNOG00000004327 (Rn)
Entrez Gene 1644 (Hs), 13195 (Mm), 24311 (Rn)
Human Protein Atlas ENSG00000132437 (Hs)
KEGG Enzyme 4.1.1.28
KEGG Gene hsa:1644 (Hs), mmu:13195 (Mm), rno:24311 (Rn)
OMIM 107930 (Hs)
Orphanet ORPHA121047 (Hs)
Pharos P20711 (Hs)
UniProtKB P20711 (Hs), O88533 (Mm), P14173 (Rn)
Wikipedia DDC (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form
PDB Id:  3RBF
Resolution:  2.9Å
Species:  Human
References:  2
Enzyme Reaction Click here for help
EC Number: 4.1.1.28 Levodopa -> dopamine + CO2
5-hydroxy-L-tryptophan -> 5-hydroxytryptamine + CO2
Description Reaction Reference
This enzyme also catalyses the following reaction: L-tryptophan -> tryptamine + CO2
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
L-tryptophan Substrate is endogenous in the given species Hs - -
levodopa Substrate is endogenous in the given species Hs - -
5-hydroxy-L-tryptophan Substrate is endogenous in the given species Hs - -
Deuterium-substituted L-DOPA Hs - - 3
Cofactors Click here for help
Cofactor Species Comments Reference
pyridoxal 5-phosphate None

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
3-hydroxybenzylhydrazine Small molecule or natural product Hs Inhibition - -
⤷
benserazide Small molecule or natural product Approved drug Click here for species-specific activity table Hs Inhibition - - 1
⤷ [1]
carbidopa Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Hs Inhibition - -
⤷
L-α-methyldopa Small molecule or natural product Approved drug Hs Inhibition - -
⤷
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Aromatic L-amino acid decarboxylase deficiency
OMIM: 608643
Orphanet: ORPHA35708

References

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1. Daidone F, Montioli R, Paiardini A, Cellini B, Macchiarulo A, Giardina G, Bossa F, Borri Voltattorni C. (2012) Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors. PLoS ONE, 7 (2): e31610. [PMID:22384042]

2. Giardina G, Montioli R, Gianni S, Cellini B, Paiardini A, Voltattorni CB, Cutruzzolà F. (2011) Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases. Proc Natl Acad Sci USA, 108 (51): 20514-9. [PMID:22143761]

3. Malmlöf T, Feltmann K, Konradsson-Geuken Å, Schneider F, Alken RG, Svensson TH, Schilström B. (2015) Deuterium-substituted L-DOPA displays increased behavioral potency and dopamine output in an animal model of Parkinson's disease: comparison with the effects produced by L-DOPA and an MAO-B inhibitor. J Neural Transm, 122 (2): 259-72. [PMID:24906468]

How to cite this page

Decarboxylases: L-Aromatic amino-acid decarboxylase . Last modified on 10/07/2018. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1271.