Synonyms: IL-1ra | interleukin-1 receptor antagonist protein | IRAP
Compound class:
Endogenous peptide in human, mouse or rat
Comment: A recombinant, non-glycosylated version of this protein is marketed as rheumatoid arthritis drug anakinra.
Species: Human
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References |
1. Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, TedgÄrd U, Cowen EW, Pham TH et al.. (2009)
An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med, 360 (23): 2426-37. [PMID:19494218] |
2. Reddy S, Jia S, Geoffrey R, Lorier R, Suchi M, Broeckel U, Hessner MJ, Verbsky J. (2009)
An autoinflammatory disease due to homozygous deletion of the IL1RN locus. N Engl J Med, 360 (23): 2438-44. [PMID:19494219] |
3. Zhang H, Maqsudi S, Rainczuk A, Duffield N, Lawrence J, Keane FM, Justa-Schuch D, Geiss-Friedlander R, Gorrell MD, Stephens AN. (2015)
Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis. FEBS J, 282 (19): 3737-57. [PMID:26175140] |