MK-0812 [Ligand Id: 9048] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3305901 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCR2 in Monkey [GtoPdb: 59] | ||||||||
| GtoPdb | Measuring inhibition of [125]I-MCP-1 binding by MK-0812 on isolated monocytes. | - | 8.35 | pIC50 | 4.5 | nM | IC50 | J Immunol Methods (2010) 352: 101-10 [PMID:19913021] |
| CCR2/C-C chemokine receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4015] [GtoPdb: 59] [UniProtKB: P41597] | ||||||||
| ChEMBL | Displacement of 0.1 nM [125I]CCL2 from human CCR2 expressing human U2OS cell membrane by scintillation spectrometry | B | 9.32 | pKd | 0.48 | nM | Kd | Eur J Med Chem (2015) 93: 121-134 [PMID:25666912] |
| ChEMBL | Displacement of 0.1 nM [125I]CCL2 from human CCR2 expressing human U2OS cell membrane by scintillation spectrometry | B | 9.26 | pKi | 0.55 | nM | Ki | Eur J Med Chem (2015) 93: 121-134 [PMID:25666912] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
