ChEMBL ligand: CHEMBL1214066
euchromatic histone lysine methyltransferase 2/Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 in Human [ChEMBL: CHEMBL6032] [GtoPdb: 2652] [UniProtKB: Q96KQ7] There should be some charts here, you may need to enable JavaScript!
euchromatic histone lysine methyltransferase 1/Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 in Human [ChEMBL: CHEMBL6031] [GtoPdb: 2651] [UniProtKB: Q9H9B1] There should be some charts here, you may need to enable JavaScript!
SET domain containing 7, histone lysine methyltransferase/Histone-lysine N-methyltransferase SETD7 in Human [ChEMBL: CHEMBL5523] [GtoPdb: 2703] [UniProtKB: Q8WTS6] There should be some charts here, you may need to enable JavaScript!
lysine methyltransferase 5A/N-lysine methyltransferase SETD8 in Human [ChEMBL: CHEMBL1795176] [GtoPdb: 2704] [UniProtKB: Q9NQR1] There should be some charts here, you may need to enable JavaScript!
protein arginine methyltransferase 3/Protein arginine N-methyltransferase 3 in Human [ChEMBL: CHEMBL5891] [GtoPdb: 1254] [UniProtKB: O60678] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
euchromatic histone lysine methyltransferase 2/Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6032] [GtoPdb: 2652] [UniProtKB: Q96KQ7]
GtoPdb	-	-	10.2	pKi	0.06	nM	Ki	J Med Chem (2010) 53: 5844-57 [PMID:20614940]
ChEMBL	Inhibition of G9a in human MDA-MB-231 cells assessed as reduction of H3K9me2 after 48 hrs by In-Cell Western assay	B	4.96	pIC50	11000	nM	IC50	J Med Chem (2011) 54: 6139-6150 [PMID:21780790]
ChEMBL	Activity at methyl transferase activity G9a by enzyme coupled S-adenocylehomocystein detection assay	B	5.05	pIC50	9000	nM	IC50	J Med Chem (2010) 53: 5844-5857 [PMID:20614940]
ChEMBL	Inhibition of methyl transferase activity of G9a assessed as inhibition of H3K9 methylation by chemiluminescence based oxygen tunneling assay	B	5.22	pIC50	6000	nM	IC50	J Med Chem (2010) 53: 5844-5857 [PMID:20614940]
ChEMBL	Inhibition of G9a assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assay	B	8.05	pIC50	9	nM	IC50	J Med Chem (2011) 54: 6139-6150 [PMID:21780790]
euchromatic histone lysine methyltransferase 1/Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6031] [GtoPdb: 2651] [UniProtKB: Q9H9B1]
ChEMBL	Activity at methyl transferase activity GLP by chemiluminescence based oxygen tunneling assay	B	7.64	pIC50	23	nM	IC50	J Med Chem (2010) 53: 5844-5857 [PMID:20614940]
ChEMBL	Activity at methyl transferase activity GLP by enzyme coupled S-adenocylehomocystein detection assay	B	7.82	pIC50	15	nM	IC50	J Med Chem (2010) 53: 5844-5857 [PMID:20614940]
SET domain containing 7, histone lysine methyltransferase/Histone-lysine N-methyltransferase SETD7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5523] [GtoPdb: 2703] [UniProtKB: Q8WTS6]
ChEMBL	Activity at methyl transferase activity SET7/9 by enzyme coupled S-adenocylehomocystein detection assay	B	4.4	pIC50	>40000	nM	IC50	J Med Chem (2010) 53: 5844-5857 [PMID:20614940]
lysine methyltransferase 5A/N-lysine methyltransferase SETD8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795176] [GtoPdb: 2704] [UniProtKB: Q9NQR1]
ChEMBL	Activity at methyl transferase activity SET8/preSet7 by enzyme coupled S-adenocylehomocystein detection assay	B	4.4	pIC50	>40000	nM	IC50	J Med Chem (2010) 53: 5844-5857 [PMID:20614940]
protein arginine methyltransferase 3/Protein arginine N-methyltransferase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5891] [GtoPdb: 1254] [UniProtKB: O60678]
ChEMBL	Activity at methyl transferase activity PRMT3 by enzyme coupled S-adenocylehomocystein detection assay	B	4.4	pIC50	>40000	nM	IC50	J Med Chem (2010) 53: 5844-5857 [PMID:20614940]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]