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ChEMBL ligand: CHEMBL489100 (BMS-561392) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ADAM10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5028] [GtoPdb: 1658] [UniProtKB: O14672] | ||||||||
ChEMBL | Inhibition of ADAM10 (unknown origin) using fluorescent substrate by fluorescence-based FRET assay | B | 6.32 | pIC50 | 480 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
ChEMBL | Inhibition of human catalytic domain of TACE assessed as inhibit the cleavage of the substrate by fluorescence-based FRET assay | B | 7.92 | pIC50 | 12 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
GtoPdb | - | - | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem (2009) 17: 444-59 [PMID:19095454] |
ChEMBL | Inhibition of TACE | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem (2009) 17: 444-459 [PMID:19095454] |
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
ChEMBL | Inhibition of MMP1 (unknown origin) by fluorescence-based FRET assay | B | 6.37 | pIC50 | 429 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
ChEMBL | Inhibition of MMP13 (unknown origin) by fluorescence-based FRET assay | B | 6.34 | pIC50 | 461 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
ChEMBL | Inhibition of MMP14 (unknown origin) by fluorescence-based FRET assay | B | 6.3 | pIC50 | 499 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
ChEMBL | Inhibition of MMP2 (unknown origin) by fluorescence-based FRET assay | B | 6.32 | pIC50 | 482 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
ChEMBL | Inhibition of MMP3 (unknown origin) by fluorescence-based FRET assay | B | 6.55 | pIC50 | 285 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
ChEMBL | Inhibition of MMP7 (unknown origin) by fluorescence-based FRET assay | B | 6.33 | pIC50 | 466 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
ChEMBL | Inhibition of MMP8 (unknown origin) by fluorescence-based FRET assay | B | 6.52 | pIC50 | 299 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
ChEMBL | Inhibition of MMP9 (unknown origin) by fluorescence-based FRET assay | B | 6.41 | pIC50 | 389 | nM | IC50 | Medchemcomm (2011) 2: 966-972 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]