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ChEMBL ligand: CHEMBL115653 (Cipemastat, RO-32-03555, RO 32-3555/000, RO-323555000) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
ChEMBL | Binding affinity to recombinant TACE | B | 6.64 | pKi | 230 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469] |
ChEMBL | Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMC | F | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469] |
ChEMBL | Inhibition of TACE | B | 6.64 | pIC50 | 230.3 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
ChEMBL | Inhibition of Matrix metalloprotease-1 (MMP1) | B | 5.15 | pKi | 7000 | nM | Ki | J Med Chem (2003) 46: 3840-3852 [PMID:12930146] |
GtoPdb | - | - | 8.5 | pKi | 3 | nM | Ki | Ann Rheum Dis (2001) 60 Suppl 3: iii62-7 [PMID:11890658] |
ChEMBL | Inhibition of matrix metalloprotease-1 (MMP-1). | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
ChEMBL | Binding affinity to recombinant MMP1 | B | 9.52 | pKi | 0.3 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469] |
ChEMBL | Inhibition of MMP1 | B | 8.64 | pIC50 | 2.3 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
ChEMBL | Inhibition of matrix metalloprotease-13 (MMP-13). | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
ChEMBL | Binding affinity to recombinant MMP13 | B | 9 | pKi | 1 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469] |
ChEMBL | Inhibition of MMP13 assessed as dissociation constant | B | 9.28 | pKi | 0.53 | nM | Ki | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
ChEMBL | Inhibition of MMP13 in presence of 1% bovine serum albumin | B | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
ChEMBL | Inhibition of MMP13 | B | 8.46 | pIC50 | 3.5 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
ChEMBL | Inhibitory activity against matrix metalloprotease-13 (MMP13) | B | 8.47 | pIC50 | 3.4 | nM | IC50 | J Med Chem (2003) 46: 3840-3852 [PMID:12930146] |
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
ChEMBL | Inhibition of MMP14 | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
ChEMBL | Inhibition of matrix metalloprotease-2 (MMP-2). | B | 6.81 | pKi | 154 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
ChEMBL | Inhibitory activity against matrix metalloprotease-2 (MMP2) | B | 6.81 | pIC50 | 154 | nM | IC50 | J Med Chem (2003) 46: 3840-3852 [PMID:12930146] |
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
ChEMBL | Inhibition of matrix metalloprotease-3 (MMP-3). | B | 6.28 | pKi | 527 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
ChEMBL | Binding affinity to recombinant MMP3 | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469] |
ChEMBL | Inhibitory activity against matrix metalloprotease-3 (MMP3) | B | 6.28 | pIC50 | 527 | nM | IC50 | J Med Chem (2003) 46: 3840-3852 [PMID:12930146] |
ChEMBL | Inhibition of MMP3 | B | 7.06 | pIC50 | 87 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
ChEMBL | Inhibition of MMP7 | B | 7.73 | pIC50 | 18.5 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
ChEMBL | Inhibition of matrix metalloprotease-8 (MMP-8). | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
ChEMBL | Inhibition of matrix metalloprotease-9 (MMP-9). | B | 7.23 | pKi | 59 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
ChEMBL | Inhibitory activity against matrix metalloprotease-9 (MMP9) | B | 7.24 | pIC50 | 58 | nM | IC50 | J Med Chem (2003) 46: 3840-3852 [PMID:12930146] |
ChEMBL | Inhibition of MMP9 | B | 8.62 | pIC50 | 2.4 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]