cipemastat [Ligand Id: 6466] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL115653 (Cipemastat, RO-32-03555, RO 32-3555/000, RO-323555000)
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  • MMP1/Matrix metalloproteinase-1 in Human [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
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  • MMP13/Matrix metalloproteinase 13 in Human [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
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  • MMP14/Matrix metalloproteinase 14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
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  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
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  • MMP3/Matrix metalloproteinase 3 in Human [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
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  • MMP9/Matrix metalloproteinase 9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536]
ChEMBL Binding affinity to recombinant TACE B 6.64 pKi 230 nM Ki Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469]
ChEMBL Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMC F 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469]
ChEMBL Inhibition of TACE B 6.64 pIC50 230.3 nM IC50 J Med Chem (2009) 52: 3523-3538 [PMID:19422229]
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
ChEMBL Inhibition of Matrix metalloprotease-1 (MMP1) B 5.15 pKi 7000 nM Ki J Med Chem (2003) 46: 3840-3852 [PMID:12930146]
GtoPdb - - 8.5 pKi 3 nM Ki Ann Rheum Dis (2001) 60 Suppl 3: iii62-7 [PMID:11890658]
ChEMBL Inhibition of matrix metalloprotease-1 (MMP-1). B 8.52 pKi 3 nM Ki J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL Binding affinity to recombinant MMP1 B 9.52 pKi 0.3 nM Ki Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469]
ChEMBL Inhibition of MMP1 B 8.64 pIC50 2.3 nM IC50 J Med Chem (2009) 52: 3523-3538 [PMID:19422229]
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
ChEMBL Inhibition of matrix metalloprotease-13 (MMP-13). B 8.52 pKi 3 nM Ki J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL Binding affinity to recombinant MMP13 B 9 pKi 1 nM Ki Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469]
ChEMBL Inhibition of MMP13 assessed as dissociation constant B 9.28 pKi 0.53 nM Ki J Med Chem (2009) 52: 3523-3538 [PMID:19422229]
ChEMBL Inhibition of MMP13 in presence of 1% bovine serum albumin B 8.33 pIC50 4.7 nM IC50 J Med Chem (2009) 52: 3523-3538 [PMID:19422229]
ChEMBL Inhibition of MMP13 B 8.46 pIC50 3.5 nM IC50 J Med Chem (2009) 52: 3523-3538 [PMID:19422229]
ChEMBL Inhibitory activity against matrix metalloprotease-13 (MMP13) B 8.47 pIC50 3.4 nM IC50 J Med Chem (2003) 46: 3840-3852 [PMID:12930146]
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
ChEMBL Inhibition of MMP14 B 7.64 pIC50 23 nM IC50 J Med Chem (2009) 52: 3523-3538 [PMID:19422229]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL Inhibition of matrix metalloprotease-2 (MMP-2). B 6.81 pKi 154 nM Ki J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL Inhibitory activity against matrix metalloprotease-2 (MMP2) B 6.81 pIC50 154 nM IC50 J Med Chem (2003) 46: 3840-3852 [PMID:12930146]
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
ChEMBL Inhibition of matrix metalloprotease-3 (MMP-3). B 6.28 pKi 527 nM Ki J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL Binding affinity to recombinant MMP3 B 7.25 pKi 56 nM Ki Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469]
ChEMBL Inhibitory activity against matrix metalloprotease-3 (MMP3) B 6.28 pIC50 527 nM IC50 J Med Chem (2003) 46: 3840-3852 [PMID:12930146]
ChEMBL Inhibition of MMP3 B 7.06 pIC50 87 nM IC50 J Med Chem (2009) 52: 3523-3538 [PMID:19422229]
MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237]
ChEMBL Inhibition of MMP7 B 7.73 pIC50 18.5 nM IC50 J Med Chem (2009) 52: 3523-3538 [PMID:19422229]
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894]
ChEMBL Inhibition of matrix metalloprotease-8 (MMP-8). B 8.4 pKi 4 nM Ki J Med Chem (2000) 43: 305-341 [PMID:10669559]
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
ChEMBL Inhibition of matrix metalloprotease-9 (MMP-9). B 7.23 pKi 59 nM Ki J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL Inhibitory activity against matrix metalloprotease-9 (MMP9) B 7.24 pIC50 58 nM IC50 J Med Chem (2003) 46: 3840-3852 [PMID:12930146]
ChEMBL Inhibition of MMP9 B 8.62 pIC50 2.4 nM IC50 J Med Chem (2009) 52: 3523-3538 [PMID:19422229]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]