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ChEMBL ligand: CHEMBL323994 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Inhibition of JAK2 | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5633-5638 [PMID:16934457] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 | B | 7.42 | pIC50 | 38 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5633-5638 [PMID:16934457] |
ChEMBL | Inhibitory activity against Janus Kinase 3 protein tyrosine kinase. | B | 7.57 | pIC50 | 27 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3105-3110 [PMID:12941344] |
leucine rich repeat kinase 2 in Human [GtoPdb: 2059] [UniProtKB: Q5S007] | ||||||||
GtoPdb | - | - | 7.66 | pIC50 | 22 | nM | IC50 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]