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ChEMBL ligand: CHEMBL3109649 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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tankyrase/Tankyrase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6164] [GtoPdb: 3108] [UniProtKB: O95271] | ||||||||
ChEMBL | Inhibition of human TNKS1 incubated for 30 mins prior to substrate addition measured after 2 hrs by HTRF method | B | 6.5 | pIC50 | 316.23 | nM | IC50 | ACS Med Chem Lett (2014) 5: 10-11 [PMID:24900768] |
GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | ACS Med Chem Lett (2021) 12: 1005-1010 [PMID:34141085] |
tankyrase 2/Tankyrase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6154] [GtoPdb: 3109] [UniProtKB: Q9H2K2] | ||||||||
ChEMBL | Inhibition of human TNKS2 incubated for 30 mins prior to substrate addition measured after 2 hrs by HTRF method | B | 7 | pIC50 | 100 | nM | IC50 | ACS Med Chem Lett (2014) 5: 10-11 [PMID:24900768] |
GtoPdb | - | - | 7.2 | pIC50 | 63.1 | nM | IC50 | ACS Med Chem Lett (2021) 12: 1005-1010 [PMID:34141085] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]